Momoa, best known for his roles in Aquaman, Game of Thrones, Dune and Fast X, arrived at Fenix, The Goods Yard on Sunday, February 1.
The 46-year-old is in the city to launched Meili Vodka, the vodka brand he co-founded.
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The trip also coincides with the Prime Video premiere of his latest action feature, The Wrecking Crew, starring opposite Dave Bautista, released this week.
Speaking about the launch Momoa said: "Meili is about quality, sustainability, and sharing a drink with good people in great places. Manchester has an incredible energy, and launching the brand here felt natural. Partnering with Permanently Unique made complete sense -- their venues and vision really align with what Meili stands for."
The Manchester launch follows a meeting between Momoa and Permanently Unique in Dubai and establishes Meili Vodka as a partner across Permanently Unique's Manchester venues, including Fenix, Louis and Tattu Manchester.
Drew Jones, of Permanently Unique, said: "We met Jason in Dubai and immediately knew there was a strong fit. Permanently Unique is about creating standout venues and unforgettable experiences, and Meili Vodka matches that ethos perfectly. We're proud to be launching the brand in Manchester and making it a permanent fixture across our venues."
Later this evening, Momoa is also expected to attend Louis, to perform with his band ÖOF TATATÁ.